When she suddenly wakes up and realizes that she has lost her memory of the previous day, Booth flies down to help her.Soon, she becomes the prime suspect in a murder case.However, Brennan and her team have trouble identifying the victim when they discover that she had extensive cosmetic surgery done, which altered the core architecture of her skull.

As the clues begin to unravel, the investigation gets more complicated when details of the man's private life are revealed, leading Brennan and Booth to a private detective who may hold key information. Camille Saroyan, a first-rate pathologist who has been hired as the head of forensics at the Jeffersonian, and more importantly, Brennan's boss.

It doesn't take long for Brennan to figure out "Cam" is a little too familiar with Booth and that they share something of a past.

Howard Epps, a death row inmate, has less than two days left before his execution.

When his attorney asks for Booth's help to prove his innocence, Booth agrees to look over the case and asks Brennan and her team to help him, even though he is convinced of Epps' guilt. After Brennan and her team help Booth identify a young woman found in a refrigerator, they proceed to find out who had killed the woman.

Through examining the human remains of the driver, Brennan and her team are able to help Agent Booth to find the killer and stop a potential terrorist act involving the President. Brennan reluctantly joins Agent Booth to travel to Washington State, where a human arm was found inside the stomach of a bear.

As Brennan identifies the man, she discovers that he might have been a victim of a cannibal.Two cases are brought to the Jeffersonian Institute; one concerning the human remains of whom the FBI thinks is mob boss James Cuguni, while the other concerns a possible murder victim of serial killer Kevin Hollings.When Brennan narrowly misses being the target of a shooting while waiting for a date, it becomes probable that the shooter is connected to one of these cases.A six-year-boy's remains is found near a shopping mall and when he is confirmed by Dr.Brennan to be the same boy who went missing from a local park, Booth and Brennan's team work together to find his murderer.Brennan and Zack investigate a small jet crash that was carrying some Chinese diplomats and an unidentified female guest.